Transport of orally administered 9,10-dimethyl-1,2-benzanthracene in the Sprague-Dawley rat.

Experimental therapeutic investigations with 1-(morpholinomethyl)-4-phthalimido-piperidindione-2,6 on dimethylbenzanthracene-induced tumors of Sprague-Dawley rats.

Neoplasms evoked in male Sprague-Dawley rat by pulse doses of 7,12-dimethylbenz(a)anthracene.

In male rats of the Sprague-Dawley strain a single pulse dose of 7,12-dimethylbenz(a)anthracene elicited a few mammary and sebaceous gland carcinomas but leukemia was not observed. Multiple pulse doses enhanced the yields of these tumors and, in addition, evoked leukemia in rather high incidence. The induced mammary cancers of male rats did not regress after orchiectomy and hypophysectomy; henc...

Influence of hypothalamic lesions on the induction and growth of mammary cancers in Sprague-Dawley rats receiving 7,12-dimethylbenz(a)anthracene.

Determination of the Number of Events Required for Mammary Carcinogenesis in the Sprague-Dawley Female Rat1

Female Sprague-Dawley rats were exposed to a single, graded dose of either of two highly effective mammary chemical carcin ogens, 7,12-dimethylbenzanthracene (DMBA) or A/-methylnitrosourea, in order to determine the number of mammary cancers per rat induced by a range of carcinogenic doses. These data were then used to separately construct dose-response curves characteristic for DMBAand A/-meth...

Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.

Sulforaphane [1-isothiocyanato-4-(methyl-sulfinyl)butane] was recently isolated from one variety of broccoli as the major and very potent inducer of phase 2 detoxication enzymes in murine hepatoma cells in culture. Since phase 2 enzyme induction is often associated with reduced susceptibility of animals and their cells to the toxic and neoplastic effects of carcinogens and other electrophiles, ...